Trichloroethanol, an active metabolite of chloral hydrate, modulates tetrodotoxin-resistant Na<sup>+</sup> channels in rat nociceptive neurons.

Kim, Gimin; Kim, Hyunjung; Jang, Il-Sung

Trichloroethanol, an active metabolite of chloral hydrate, modulates tetrodotoxin-resistant Na⁺ channels in rat nociceptive neurons.

Kim, Gimin; Kim, Hyunjung; Jang, Il-Sung.

Afiliação

Kim G; Department of Pediatric Dentistry, School of Dentistry, Kyungpook National University, Daegu, 41940, Republic of Korea.
Kim H; Department of Pediatric Dentistry, School of Dentistry, Kyungpook National University, Daegu, 41940, Republic of Korea.
Jang IS; Department of Pharmacology, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, Republic of Korea. jis7619@knu.ac.kr.

BMC Anesthesiol ; 23(1): 145, 2023 04 29.

Article em En | MEDLINE | ID: mdl-37120567

Assuntos

Nociceptores; Canais de Sódio; Ratos; Animais; Tetrodotoxina/farmacologia; Tetrodotoxina/metabolismo; Nociceptores/metabolismo; Canais de Sódio/metabolismo; Canais de Sódio/farmacologia; Hidrato de Cloral/farmacologia; Hidrato de Cloral/metabolismo; Potenciais da Membrana/fisiologia; Ratos Sprague-Dawley; Gânglios Espinais/metabolismo

Palavras-chave

Analgesia; Chloral hydrate; Nociceptive neurons; Patch clamp; TTX-R Na+ channels; Trichloroethanol

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nociceptores / Canais de Sódio Limite: Animals Idioma: En Revista: BMC Anesthesiol Ano de publicação: 2023 Tipo de documento: Article

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