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Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Datta, Dhrubajyoti; Theile, Christopher S; Wassarman, Kelly; Qin, June; Racie, Tim; Schmidt, Karyn; Jiang, Yongfeng; Sigel, Rachel; Janas, Maja M; Egli, Martin; Manoharan, Muthiah.
Afiliação
  • Datta D; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Theile CS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Wassarman K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Racie T; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Schmidt K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Jiang Y; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Sigel R; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Janas MM; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
  • Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.
  • Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
Chem Commun (Camb) ; 59(42): 6347-6350, 2023 May 23.
Article em En | MEDLINE | ID: mdl-37144553
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexo de Inativação Induzido por RNA / RNA Interferente Pequeno Limite: Animals Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexo de Inativação Induzido por RNA / RNA Interferente Pequeno Limite: Animals Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos