Platycodin D inhibits HFD/STZ-induced diabetic nephropathy via inflammatory and apoptotic signaling pathways in C57BL/6 mice.

Shen, Qiong; Qi, Si-Min; Zhang, Jing-Tian; Li, Ming-Han; Wang, Ying-Ping; Wang, Zi; Li, Wei

Shen, Qiong; Qi, Si-Min; Zhang, Jing-Tian; Li, Ming-Han; Wang, Ying-Ping; Wang, Zi; Li, Wei.

Afiliação

Shen Q; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun, 130118, China.
Qi SM; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Zhang JT; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Li MH; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Wang YP; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun, 130118, China.
Wang Z; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Li W; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun, 130118, China. Electronic address: liwei7727@126.com.

J Ethnopharmacol ; 314: 116596, 2023 Oct 05.

Article em En | MEDLINE | ID: mdl-37146841

Assuntos

Diabetes Mellitus Experimental; Nefropatias Diabéticas; Camundongos; Animais; Nefropatias Diabéticas/tratamento farmacológico; Nefropatias Diabéticas/prevenção & controle; Nefropatias Diabéticas/metabolismo; NF-kappa B/metabolismo; Estreptozocina/farmacologia; Dieta Hiperlipídica; Simulação de Acoplamento Molecular; Diabetes Mellitus Experimental/metabolismo; Camundongos Endogâmicos C57BL; Transdução de Sinais; Glucose/farmacologia; Apoptose; Lipídeos/farmacologia

Palavras-chave

Apoptotic pathways; Diabetic nephropathy; Molecular docking; Molecular dynamics; NF-κB pathway; Platycodin D

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Nefropatias Diabéticas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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