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Antibiotic treatment inhibits paclitaxel chemotherapy-induced activity deficits in female mice.
Grant, Corena V; Jordan, Kelley; Seng, Melina M; Pyter, Leah M.
Afiliação
  • Grant CV; Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio, United States of America.
  • Jordan K; Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio, United States of America.
  • Seng MM; Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio, United States of America.
  • Pyter LM; Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio, United States of America.
PLoS One ; 18(5): e0284365, 2023.
Article em En | MEDLINE | ID: mdl-37167214
Chemotherapy, a mainstay in the treatment of cancer, is associated with severe and debilitating side effects. Side effects can be physical (e.g., gastrointestinal distress, anemia, and hair loss) or mental (e.g., fatigue, cognitive dysfunction). Chemotherapy is known to alter the gut microbiota; thus, communication through the gut-brain axis may influence behavioral side effects. Here, we used a clinically-relevant paclitaxel chemotherapy regimen in combination with antibiotics to test the hypothesis that gut microbes contribute to chemotherapy-associated fatigue-like behaviors in female mice. Data presented suggest that chemotherapy-altered gut microbes contribute to fatigue-like behaviors in mice by disrupting energy homeostasis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Disfunção Cognitiva / Antineoplásicos Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Disfunção Cognitiva / Antineoplásicos Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos