Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis.

Zhong, Miao; Chen, Lingzhen; Tao, Yue; Zhao, Jintao; Chang, Bingbing; Zhang, Fang; Tu, Jingwen; Cai, Wenqing; Zhang, Baoxin

Zhong, Miao; Chen, Lingzhen; Tao, Yue; Zhao, Jintao; Chang, Bingbing; Zhang, Fang; Tu, Jingwen; Cai, Wenqing; Zhang, Baoxin.

Afiliação

Zhong M; The State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Chen L; The State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Tao Y; The State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Zhao J; The State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Chang B; The State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Zhang F; The State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Tu J; The State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Cai W; Regor Therapeutics Inc, 1206 Zhangjiang Road, Building C, Pu Dong New District, Shanghai 201210, China. Electronic address: wenqing.cai@qlregor.com.
Zhang B; The State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China. Electronic address: zhangbx@lzu.edu.cn.

Bioorg Chem ; 138: 106589, 2023 09.

Article em En | MEDLINE | ID: mdl-37320912

Assuntos

Neoplasias; Tiorredoxina Dissulfeto Redutase; Humanos; Células HeLa; Estresse Oxidativo; Espécies Reativas de Oxigênio/metabolismo; Apoptose

Palavras-chave

Apoptosis; Oxidative stress; Piperine analogs; Reactive oxygen species; Thioredoxin reductase inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiorredoxina Dissulfeto Redutase / Neoplasias Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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