Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea.

Williams, Frank B; Kader, Md Abdul; Dickson, Dorothy M; Colgate, E Ross; Alam, Masud; Haque, Rashidul; Petri, William A; Kirkpatrick, Beth D; Lee, Benjamin

Williams, Frank B; Kader, Md Abdul; Dickson, Dorothy M; Colgate, E Ross; Alam, Masud; Haque, Rashidul; Petri, William A; Kirkpatrick, Beth D; Lee, Benjamin.

Afiliação

Williams FB; Vaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Kader MA; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Dickson DM; Vaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Colgate ER; Vaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Alam M; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Haque R; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Petri WA; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Kirkpatrick BD; Vaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Lee B; Vaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Open Forum Infect Dis ; 10(6): ofad299, 2023 Jun.

Article em En | MEDLINE | ID: mdl-37333724

RESUMO

Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response.

Palavras-chave

breast milk; oral vaccination; rotavirus; secretor status

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google