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Human Epidermal Growth Factor Receptor 2/Human Epidermal Growth Factor Receptor 3 PET Imaging: Challenges and Opportunities.
Ducharme, Maxwell; Mansur, Ameer; Sligh, Luke; Ulaner, Gary A; Lapi, Suzanne E; Sorace, Anna G.
Afiliação
  • Ducharme M; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Mansur A; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Sligh L; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Ulaner GA; Molecular Imaging and Therapy, Hoag Family Cancer Institute, Irvine, CA, USA; Department of Radiology and Translational Genomics, University of Southern California, Los Angeles, CA, USA.
  • Lapi SE; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: lapi@uab.edu.
  • Sorace AG; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: asorace@uabmc.edu.
PET Clin ; 18(4): 543-555, 2023 Oct.
Article em En | MEDLINE | ID: mdl-37339919
ABSTRACT
Human epidermal growth factor receptor 2 (HER2) and HER3 provide actionable targets for both therapy and imaging in breast cancer. Further, clinical trials have shown the prognostic impact of receptor status discordance in breast cancer. Intra- and intertumoral heterogeneity of both HER and hormone receptor expression contributes to inherent errors in tissue sampling, and single biopsies are incapable of identifying discordance in biomarker expression. Numerous PET radiopharmaceuticals have been developed to evaluate (or target for therapy) HER2 and HER3 expression. This review seeks to inform on challenges and opportunities in HER2 and HER3 PET imaging in both clinical and preclinical settings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Tomografia por Emissão de Pósitrons Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: PET Clin Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Tomografia por Emissão de Pósitrons Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: PET Clin Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos