Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity.
Aging Cell
; 23(1): e13916, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37400997
ABSTRACT
Somatic mutations accumulate with age and are associated closely with human health, their characterization in longevity cohorts remains largely unknown. Here, by analyzing whole genome somatic mutation profiles in 73 centenarians and 51 younger controls in China, we found that centenarian genomes are characterized by a markedly skewed distribution of somatic mutations, with many genomic regions being specifically conserved but displaying a high function potential. This, together with the observed more efficient DNA repair ability in the long-lived individuals, supports the existence of key genomic regions for human survival during aging, with their integrity being of essential to human longevity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Centenários
/
Longevidade
Limite:
Aged80
/
Humans
Idioma:
En
Revista:
Aging Cell
Ano de publicação:
2024
Tipo de documento:
Article