Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies <i>FIXER</i>, a Conserved Profibrogenic Long Noncoding RNA.

Aghagolzadeh, Parisa; Plaisance, Isabelle; Bernasconi, Riccardo; Treibel, Thomas A; Pulido Quetglas, Carlos; Wyss, Tania; Wigger, Leonore; Nemir, Mohamed; Sarre, Alexandre; Chouvardas, Panagiotis; Johnson, Rory; González, Arantxa; Pedrazzini, Thierry

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA.

Aghagolzadeh, Parisa; Plaisance, Isabelle; Bernasconi, Riccardo; Treibel, Thomas A; Pulido Quetglas, Carlos; Wyss, Tania; Wigger, Leonore; Nemir, Mohamed; Sarre, Alexandre; Chouvardas, Panagiotis; Johnson, Rory; González, Arantxa; Pedrazzini, Thierry.

Afiliação

Aghagolzadeh P; Experimental Cardiology Unit, Division of Cardiology, Department of Cardiovascular Medicine, University of Lausanne Medical School, Switzerland (P.A., I.P., R.B., M.N., T.P.).
Plaisance I; Experimental Cardiology Unit, Division of Cardiology, Department of Cardiovascular Medicine, University of Lausanne Medical School, Switzerland (P.A., I.P., R.B., M.N., T.P.).
Bernasconi R; Experimental Cardiology Unit, Division of Cardiology, Department of Cardiovascular Medicine, University of Lausanne Medical School, Switzerland (P.A., I.P., R.B., M.N., T.P.).
Treibel TA; Institute of Cardiovascular Sciences, University College London, United Kingdom (T.A.T.).
Pulido Quetglas C; Department for BioMedical Research, University of Bern, Switzerland (C.P.Q., P.C., R.J.).
Wyss T; Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland (T.W.).
Wigger L; Swiss Institute of Bioinformatics, Lausanne, Switzerland (T.W., L.W.).
Nemir M; Swiss Institute of Bioinformatics, Lausanne, Switzerland (T.W., L.W.).
Sarre A; Experimental Cardiology Unit, Division of Cardiology, Department of Cardiovascular Medicine, University of Lausanne Medical School, Switzerland (P.A., I.P., R.B., M.N., T.P.).
Chouvardas P; Cardiovascular Assessment Facility, University of Lausanne, Switzerland (A.S.).
Johnson R; Department for BioMedical Research, University of Bern, Switzerland (C.P.Q., P.C., R.J.).
González A; Department for BioMedical Research, University of Bern, Switzerland (C.P.Q., P.C., R.J.).
Pedrazzini T; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA, Pamplona, Spain (A.G.).

Circulation ; 148(9): 778-797, 2023 08 29.

Article em En | MEDLINE | ID: mdl-37427428

Assuntos

Cardiomiopatias; RNA Longo não Codificante; Animais; Humanos; Transcriptoma; RNA Longo não Codificante/genética; RNA Longo não Codificante/metabolismo; Cardiomiopatias/genética; Fibrose; Análise de Sequência de RNA; Fatores de Transcrição/genética; Infarto; Mamíferos/genética; Mamíferos/metabolismo; Ligases/genética; Ligases/metabolismo; Proteínas do Grupo Polycomb/genética; Proteínas do Grupo Polycomb/metabolismo

Palavras-chave

RNA, long noncoding; fibrosis; heart; single-cell analysis; therapeutics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Longo não Codificante / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Circulation Ano de publicação: 2023 Tipo de documento: Article

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