High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance.

Zaghmi, Ahlem; Aybay, Erdem; Jiang, Long; Shang, Mingmei; Steinmetz-Späh, Julia; Wermeling, Fredrik; Kogner, Per; Korotkova, Marina; Östling, Päivi; Jakobsson, Per-Johan; Seashore-Ludlow, Brinton; Larsson, Karin

Zaghmi, Ahlem; Aybay, Erdem; Jiang, Long; Shang, Mingmei; Steinmetz-Späh, Julia; Wermeling, Fredrik; Kogner, Per; Korotkova, Marina; Östling, Päivi; Jakobsson, Per-Johan; Seashore-Ludlow, Brinton; Larsson, Karin.

Afiliação

Zaghmi A; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Aybay E; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jiang L; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Shang M; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Steinmetz-Späh J; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Wermeling F; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Kogner P; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Korotkova M; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Östling P; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Jakobsson PJ; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Seashore-Ludlow B; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Larsson K; Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Mol Oncol ; 18(2): 317-335, 2024 Feb.

Article em En | MEDLINE | ID: mdl-37519014

Assuntos

Resistencia a Medicamentos Antineoplásicos; Neuroblastoma; Humanos; Prostaglandina-E Sintases; Esferoides Celulares; Neuroblastoma/tratamento farmacológico; Descoberta de Drogas/métodos

Palavras-chave

MCTS; PGE2; drug screen; mPGES-1; neuroblastoma; spheroids

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Neuroblastoma Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Mol Oncol Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suécia

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