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Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors.
Burmistrov, Vladimir V; Morisseau, Christophe; Shkineva, Tatyana K; Danilov, Dmitry V; Gladkikh, Boris; Butov, Gennady M; Fayzullin, Robert R; Dutova, Tatyana Ya; Hammock, Bruce D; Dalinger, Igor L.
Afiliação
  • Burmistrov VV; Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
  • Morisseau C; Department of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, 42a Engels Street, Volzhsky, 404121, Russia.
  • Shkineva TK; Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
  • Danilov DV; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Lenin Avenue, Moscow 119991, Russia.
  • Gladkikh B; Department of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, 42a Engels Street, Volzhsky, 404121, Russia.
  • Butov GM; Department of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, 42a Engels Street, Volzhsky, 404121, Russia.
  • Fayzullin RR; Department of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, 42a Engels Street, Volzhsky, 404121, Russia.
  • Dutova TY; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 8 Arbuzov Street, Kazan, 420088, Russia.
  • Hammock BD; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Lenin Avenue, Moscow 119991, Russia.
  • Dalinger IL; Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
J Fluor Chem ; 2662023 Feb.
Article em En | MEDLINE | ID: mdl-37638129
ABSTRACT
A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.5 nM. 1-Adamantyl-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]urea (3f, IC50 = 0.8 nM) and 1-[(Adamantan-1-yl)methyl]-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]urea (4f, IC50 = 1.2 nM) were found to be the most potent sEH inhibitors within the described series.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Fluor Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Fluor Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos