LMP2-mRNA lipid nanoparticle sensitizes EBV-related tumors to anti-PD-1 therapy by reversing T cell exhaustion.

Xiang, Yu; Tian, Miaomiao; Huang, Juan; Li, Yueyi; Li, Guangqi; Li, Xue; Jiang, Zedong; Song, Xiangrong; Ma, Xuelei

Xiang, Yu; Tian, Miaomiao; Huang, Juan; Li, Yueyi; Li, Guangqi; Li, Xue; Jiang, Zedong; Song, Xiangrong; Ma, Xuelei.

Afiliação

Xiang Y; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Tian M; Department of Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Huang J; Department of Hematology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Li Y; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Li G; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Li X; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jiang Z; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Song X; Department of Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China. songxr@scu.edu.cn.
Ma X; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. drmaxuelei@gmail.com.

J Nanobiotechnology ; 21(1): 324, 2023 Sep 08.

Article em En | MEDLINE | ID: mdl-37679769

Assuntos

Herpesvirus Humano 4; Neoplasias Nasofaríngeas; Animais; Camundongos; Herpesvirus Humano 4/genética; Exaustão das Células T; Inibidores de Checkpoint Imunológico/farmacologia; Carcinoma Nasofaríngeo/tratamento farmacológico; RNA Mensageiro/genética; Neoplasias Nasofaríngeas/tratamento farmacológico; Microambiente Tumoral

Palavras-chave

Combined therapy; EBV; Immunotherapy; Lymph node targeting; Nasopharyngeal carcinoma; PD-1; mRNA vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Herpesvirus Humano 4 Limite: Animals Idioma: En Revista: J Nanobiotechnology Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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