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3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation.
Wesseler, Milan Finn; Taebnia, Nayere; Harrison, Sean; Youhanna, Sonia; Preiss, Lena C; Kemas, Aurino M; Vegvari, Akos; Mokry, Jaroslav; Sullivan, Gareth J; Lauschke, Volker M; Larsen, Niels B.
Afiliação
  • Wesseler MF; Department of Health Technology, DTU Health Tech, Technical University of Denmark, Kgs, Lyngby, Denmark.
  • Taebnia N; Department of Health Technology, DTU Health Tech, Technical University of Denmark, Kgs, Lyngby, Denmark.
  • Harrison S; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.
  • Youhanna S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Preiss LC; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Drug Metabolism and Pharmacokinetics (DMPK), the healthcare business of Merck KGaA, Darmstadt, Germany.
  • Kemas AM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Vegvari A; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Mokry J; Department of Histology and Embryology, Faculty of Medicine in Hradec Králové, Charles University, Hradec, Králové, Czech Republic.
  • Sullivan GJ; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway. Electronic address: gareth.sullivan@medisin.uio.no.
  • Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany. Electronic address: volker.lauschke@ki.se.
  • Larsen NB; Department of Health Technology, DTU Health Tech, Technical University of Denmark, Kgs, Lyngby, Denmark. Electronic address: nibl@dtu.dk.
Acta Biomater ; 171: 336-349, 2023 11.
Article em En | MEDLINE | ID: mdl-37734628
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatócitos / Fígado Limite: Humans Idioma: En Revista: Acta Biomater Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatócitos / Fígado Limite: Humans Idioma: En Revista: Acta Biomater Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca