Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation.

Lim, Christine M; González Díaz, Alicia; Fuxreiter, Monika; Pun, Frank W; Zhavoronkov, Alex; Vendruscolo, Michele

Lim, Christine M; González Díaz, Alicia; Fuxreiter, Monika; Pun, Frank W; Zhavoronkov, Alex; Vendruscolo, Michele.

Afiliação

Lim CM; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
González Díaz A; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Fuxreiter M; Department of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Pun FW; Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong, China.
Zhavoronkov A; Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong, China.
Vendruscolo M; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

Proc Natl Acad Sci U S A ; 120(40): e2300215120, 2023 10 03.

Article em En | MEDLINE | ID: mdl-37774095

Assuntos

Doença de Alzheimer; Multiômica; Humanos; Proteínas; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/genética; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina

Palavras-chave

Alzheimer's disease; FuzDrop; PandaOmics; phase separation; therapeutic targets

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Multiômica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido

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