Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis.

Richardson, Peter J; Smith, Daniel P; de Giorgio, Alex; Snetkov, Xenia; Almond-Thynne, Joshua; Cronin, Sara; Mead, Richard J; McDermott, Christopher J; Shaw, Pamela J

Richardson, Peter J; Smith, Daniel P; de Giorgio, Alex; Snetkov, Xenia; Almond-Thynne, Joshua; Cronin, Sara; Mead, Richard J; McDermott, Christopher J; Shaw, Pamela J.

Afiliação

Richardson PJ; BenevolentAI, 4-8 Maple Street, London, W1T 5HD, UK. peter.richardson@benevolent.ai.
Smith DP; BenevolentAI, 4-8 Maple Street, London, W1T 5HD, UK.
de Giorgio A; BenevolentAI, 4-8 Maple Street, London, W1T 5HD, UK.
Snetkov X; BenevolentAI, 4-8 Maple Street, London, W1T 5HD, UK.
Almond-Thynne J; BenevolentAI, 4-8 Maple Street, London, W1T 5HD, UK.
Cronin S; BenevolentAI, 15 MetroTech Centre, 8th FL, Brooklyn, NY, 11201, USA.
Mead RJ; Sheffield Institute for Translational Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.
McDermott CJ; Sheffield Institute for Translational Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.
Shaw PJ; NIHR Sheffield Biomedical Research Centre, University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Transl Neurodegener ; 12(1): 47, 2023 10 12.

Article em En | MEDLINE | ID: mdl-37828541

Assuntos

Esclerose Lateral Amiotrófica; Inibidores de Janus Quinases; Doenças Neurodegenerativas; Humanos; Esclerose Lateral Amiotrófica/tratamento farmacológico; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/metabolismo; Inibidores de Janus Quinases/uso terapêutico; Sistema Nervoso Central/metabolismo; Janus Quinases/metabolismo; Janus Quinases/uso terapêutico

Palavras-chave

Amyotrophic lateral sclerosis; Janus kinase; STAT3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Inibidores de Janus Quinases / Esclerose Lateral Amiotrófica Limite: Humans Idioma: En Revista: Transl Neurodegener Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido

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