Low-moderate dose whole-brain Î³-ray irradiation modulates the expressions of glial fibrillary acidic protein and intercellular adhesion molecule-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model.

Park, Mijeong; Ha, Jimin; Lee, Yuri; Choi, Hoon-Seong; Kim, Byoung Soo; Jeong, Youn Kyoung

Park, Mijeong; Ha, Jimin; Lee, Yuri; Choi, Hoon-Seong; Kim, Byoung Soo; Jeong, Youn Kyoung.

Afiliação

Park M; Radiological and Medical Support Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
Ha J; Radiological and Medical Support Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea; Division of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.
Lee Y; Radiological and Medical Support Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea; Division of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.
Choi HS; Research Animal Resource Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Kim BS; Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
Jeong YK; Radiological and Medical Support Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea. Electronic address: amy3523@kirams.re.kr.

Neurobiol Aging ; 132: 175-184, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37837733

Assuntos

Encéfalo; Proteína Glial Fibrilar Ácida; Doença de Parkinson; Animais; Camundongos; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina/metabolismo; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina/farmacologia; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina/uso terapêutico; Encéfalo/metabolismo; Encéfalo/efeitos da radiação; Modelos Animais de Doenças; Neurônios Dopaminérgicos/patologia; Proteína Glial Fibrilar Ácida/metabolismo; Molécula 1 de Adesão Intercelular/metabolismo; Molécula 1 de Adesão Intercelular/farmacologia; Molécula 1 de Adesão Intercelular/uso terapêutico; Camundongos Endogâmicos C57BL; Doença de Parkinson/metabolismo; Doença de Parkinson/radioterapia; Substância Negra/metabolismo

Palavras-chave

GFAP; ICAM-1 (CD54); Low-moderate dose radiation therapy; Neuroinflammation; Parkinson's disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Encéfalo / Proteína Glial Fibrilar Ácida Limite: Animals Idioma: En Revista: Neurobiol Aging Ano de publicação: 2023 Tipo de documento: Article

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