Control of glnA (glutamine synthetase) expression by urea in non-pathogenic and uropathogenic Escherichia coli.
J Bacteriol
; 205(11): e0026823, 2023 11 21.
Article
em En
| MEDLINE
| ID: mdl-37902379
ABSTRACT
IMPORTANCE The bacteria that cause urinary tract infections often become resistant to antibiotic treatment, and genes expressed during an infection could suggest non-antibiotic targets. During growth in urine, glnA (specifying glutamine synthetase) expression is high, but our results show that urea induces glnA expression independent of the regulation that responds to nitrogen limitation. Although our results suggest that glnA is an unlikely target for therapy because of variation in urinary components between individuals, our analysis of glnA expression in urine-like environments has revealed previously undescribed layers of regulation. In other words, regulatory mechanisms that are discovered in a laboratory environment do not necessarily operate in the same way in nature.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escherichia coli Uropatogênica
/
Glutamato-Amônia Ligase
Limite:
Humans
Idioma:
En
Revista:
J Bacteriol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos