mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice.
NPJ Vaccines
; 8(1): 167, 2023 Oct 31.
Article
em En
| MEDLINE
| ID: mdl-37907507
ABSTRACT
We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective and successful SFTS vaccine candidate.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
NPJ Vaccines
Ano de publicação:
2023
Tipo de documento:
Article