Deficiency of inflammation-sensing protein neuropilin-2 in myeloid-derived macrophages exacerbates colitis via NF-&#954;B activation.

Li, Tong; Ran, Jingjing; Miao, Zhiyong; Yang, Min; Mou, Dachao; Jiang, Yunhan; Xu, Xiaoqiu; Xie, Qibing; Jin, Ke

Deficiency of inflammation-sensing protein neuropilin-2 in myeloid-derived macrophages exacerbates colitis via NF-κB activation.

Li, Tong; Ran, Jingjing; Miao, Zhiyong; Yang, Min; Mou, Dachao; Jiang, Yunhan; Xu, Xiaoqiu; Xie, Qibing; Jin, Ke.

Afiliação

Li T; Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, PR China.
Ran J; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, PR China.
Miao Z; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, PR China.
Yang M; West China Medical Publishers, West China Hospital of Sichuan University, Chengdu, PR China.
Mou D; Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, PR China.
Jiang Y; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, PR China.
Xu X; Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, PR China.
Xie Q; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, PR China.
Jin K; Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, PR China.

J Pathol ; 262(2): 175-188, 2024 02.

Article em En | MEDLINE | ID: mdl-37946610

Assuntos

Colite; NF-kappa B; Humanos; Animais; Camundongos; NF-kappa B/metabolismo; Neuropilina-2/genética; Neuropilina-2/metabolismo; Colite/patologia; Inflamação/patologia; Macrófagos/patologia; Sulfato de Dextrana/toxicidade; Sulfato de Dextrana/metabolismo; Camundongos Endogâmicos C57BL; Modelos Animais de Doenças

Palavras-chave

IBD; NF-κB; TNF-α; colitis; inflammation; inflammation restriction; inflammation-sensing protein; macrophage; myeloid cells; neuropilin-2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Colite Limite: Animals / Humans Idioma: En Revista: J Pathol Ano de publicação: 2024 Tipo de documento: Article

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