Metacaspase (Pf MCA-1) as antimalarial drug target: An in silico approach and their biological validation.

Yadav, Kanchan; Kuldeep, Jitendra; Shabeer Ali, H; Siddiqi, Mohammad Imran; Tripathi, Renu

Yadav, Kanchan; Kuldeep, Jitendra; Shabeer Ali, H; Siddiqi, Mohammad Imran; Tripathi, Renu.

Afiliação

Yadav K; Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Kuldeep J; Division of Biochemistry and Structural Biology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Shabeer Ali H; Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Siddiqi MI; Division of Biochemistry and Structural Biology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Tripathi R; Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India. Electronic address: renu_tripathi@cdri.res.in.

Life Sci ; 335: 122271, 2023 Dec 15.

Article em En | MEDLINE | ID: mdl-37977356

Assuntos

Antimaláricos; Malária; Humanos; Antimaláricos/farmacologia; Espécies Reativas de Oxigênio; Malária/parasitologia; Caspases/genética; Plasmodium falciparum/genética

Palavras-chave

Apoptosis and drug discovery; Malaria; Maybridge library; Metacaspase; Plasmodium

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Malária / Antimaláricos Limite: Humans Idioma: En Revista: Life Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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