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Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation.
Castro, Patricia; Corredor, Germán; Koyuncu, Can; Nordstrom, Luke A; Tiji, Michelle; Leavitt, Taylor; Lewis, James S; Madabhushi, Anant; Frederick, Mitchell J; Sandulache, Vlad C.
Afiliação
  • Castro P; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
  • Corredor G; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
  • Koyuncu C; Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
  • Nordstrom LA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
  • Tiji M; Michael E. DeBakey Veterans Affairs Medical Center, ENT Section, Operative Care Line, Houston, TX, USA.
  • Leavitt T; Michael E. DeBakey Veterans Affairs Medical Center, ENT Section, Operative Care Line, Houston, TX, USA.
  • Lewis JS; Bobby R. Alford Department of Otolaryngology- Head and Neck Surgery, Baylor College of Medicine, 1977 Butler Blvd. 5th Floor, Ste E5.200, Houston, TX, 77030, USA.
  • Madabhushi A; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Frederick MJ; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Sandulache VC; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Head Neck Pathol ; 17(4): 952-960, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37995073
OBJECTIVE: Oropharyngeal squamous cell carcinoma (OPSCC) recurrence is almost universally fatal. Development of effective therapeutic options requires an improved understanding of recurrent OPSCC biology. METHODS: We analyzed paired primary-recurrent OPSCC from Veterans treated at the Michael E. DeBakey Veterans Affairs Medical Center between 2000 and 2020 who received curative intent radiation-based treatment (with or without chemotherapy). Patient tumors were analyzed using standard immunohistochemistry and automated imaging of infiltrating lymphocytes and multinucleated tumor cells coupled to machine learning algorithms. RESULTS: Primary and recurrent tumors demonstrated high concordance via p16 and p53 immunohistochemistry, with comparable levels of multinucleation. In contrast, recurrent tumors demonstrated significantly higher levels of CD8+ tumor infiltrating lymphocytes (p<0.05) and higher levels of PD-L1 expression (p<0.05). CONCLUSION: Exposure to chemo-radiation and recurrence following treatment preserves critical features of intrinsic tumor biology and the tumor immune microenvironment suggesting that novel treatment regimens may be as effective in the salvage setting as in the definitive intent setting.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Orofaríngeas / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Revista: Head Neck Pathol Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Orofaríngeas / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Revista: Head Neck Pathol Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos