Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4<sup>+</sup> T cells with brain-homing capacity.

Hoeks, Cindy; Puijfelik, Fabiënne van; Koetzier, Steven C; Rip, Jasper; Corsten, Cato E A; Wierenga-Wolf, Annet F; Melief, Marie-José; Stinissen, Piet; Smolders, Joost; Hellings, Niels; Broux, Bieke; van Luijn, Marvin M

Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4⁺ T cells with brain-homing capacity.

Hoeks, Cindy; Puijfelik, Fabiënne van; Koetzier, Steven C; Rip, Jasper; Corsten, Cato E A; Wierenga-Wolf, Annet F; Melief, Marie-José; Stinissen, Piet; Smolders, Joost; Hellings, Niels; Broux, Bieke; van Luijn, Marvin M.

Afiliação

Hoeks C; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Puijfelik FV; University MS Center (UMSC), Hasselt, Belgium.
Koetzier SC; Department of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Rip J; Department of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Corsten CEA; Department of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Wierenga-Wolf AF; Department of Neurology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Melief MJ; Department of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Stinissen P; Department of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Smolders J; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Hellings N; University MS Center (UMSC), Hasselt, Belgium.
Broux B; Department of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
van Luijn MM; Department of Neurology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Eur J Immunol ; 54(2): e2350544, 2024 Feb.

Article em En | MEDLINE | ID: mdl-38009648

Assuntos

Antígenos CD28; Esclerose Múltipla; Humanos; Encéfalo/patologia; Antígenos CD28/metabolismo; Linfócitos T CD4-Positivos/metabolismo; Subunidade alfa 3 de Fator de Ligação ao Core/metabolismo; Granzimas/metabolismo; Esclerose Múltipla/genética

Palavras-chave

CD4+CD28−; Eomes; Multiple sclerosis; Pathogenic CD4+ T cells; Runx3; T-bet; Th17.1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos CD28 / Esclerose Múltipla Limite: Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bélgica

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