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Transfusions in autoimmune hemolytic anemias: Frequency and clinical significance of alloimmunization.
Versino, Francesco; Revelli, Nicoletta; Villa, Stefania; Pettine, Loredana; Zaninoni, Anna; Prati, Daniele; Passamonti, Francesco; Barcellini, Wilma; Fattizzo, Bruno.
Afiliação
  • Versino F; Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Revelli N; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
  • Villa S; Immune-Hematology Service, Tranfusion Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Pettine L; Immune-Hematology Service, Tranfusion Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Zaninoni A; Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Prati D; Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Passamonti F; Immune-Hematology Service, Tranfusion Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Barcellini W; Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Fattizzo B; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
J Intern Med ; 295(3): 369-374, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38013593
BACKGROUND: Autoimmune hemolytic anemia (AIHA) may be associated with transfusion reactions and risk of alloimmunization. OBJECTIVES: To evaluate the transfusion policy and rate of alloimmunization and its clinical significance in AIHA. METHODS: Data from 305 AIHA patients followed at a reference hematologic Center in Milan, Italy from 1997 to 2022 were retrospectively/prospectively collected (NCT05931718). RESULTS: Overall, 33% patients required transfusions with a response rate of 83% and eight transfusion reactions (7%), none hemolytic. Alloantibodies were detected in 19% of patients, being associated with higher transfusion burden (p = 0.01), lower Hb increase post-transfusion (p = 0.05), and transfusion reactions (p = 0.04). Along decades, the rate of RBC transfusions decreased from 53% to 20% and that of alloimmunization dropped from 30% to 6% likely due to the adoption of prestorage leukoreduction, the use of more restrictive Hb thresholds, and the implementation of molecular typing. CONCLUSIONS: Severe symptomatic AIHA may be safely transfused provided appropriate matching of patients and donors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reação Transfusional / Anemia Hemolítica Autoimune Limite: Humans Idioma: En Revista: J Intern Med Assunto da revista: MEDICINA INTERNA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reação Transfusional / Anemia Hemolítica Autoimune Limite: Humans Idioma: En Revista: J Intern Med Assunto da revista: MEDICINA INTERNA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália