TFAM mislocalization during spermatogenesis.

Kavoosi, Sam; Picard, Martin; Kaufman, Brett A

Kavoosi, Sam; Picard, Martin; Kaufman, Brett A.

Afiliação

Kavoosi S; Center for Metabolism and Mitochondrial Medicine, Vascular Medicine Institute, Division of Cardiology, University of Pittsburgh School of Medicine, 200 Lothrop St. BST W1044, Pittsburgh, PA 15261, USA.
Picard M; Division of Behavioral Medicine, Department of Psychiatry, Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA.
Kaufman BA; Center for Metabolism and Mitochondrial Medicine, Vascular Medicine Institute, Division of Cardiology, University of Pittsburgh School of Medicine, 200 Lothrop St. BST W1044, Pittsburgh, PA 15261, USA. Electronic address: bkauf@pitt.edu.

Trends Genet ; 40(2): 112-114, 2024 02.

Article em En | MEDLINE | ID: mdl-38036338

ABSTRACT

ABSTRACT

Mitochondrial DNA (mtDNA) is inherited almost exclusively from the maternal lineage. Paternal destruction of either mtDNA or whole mitochondria has been the dominant model for mtDNA transmission. Recently, Lee et al. provided evidence for mitochondrial transcription factor A (TFAM) import sequence regulation as a potential cause for mtDNA depletion in human sperm before fertilization.

Assuntos

Sêmen; Espermatogênese; Masculino; Humanos; Espermatogênese/genética; Espermatozoides/metabolismo; DNA Mitocondrial/genética; Mitocôndrias/genética; Proteínas Mitocondriais/genética; Proteínas de Ligação a DNA/metabolismo; Fatores de Transcrição/metabolismo

Palavras-chave

TFAM; mtDNA; spermatogenesis; uniparental inheritance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sêmen / Espermatogênese Limite: Humans / Male Idioma: En Revista: Trends Genet Assunto da revista: GENETICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

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