Efficiency of natural oils as alternative adjuvants to mineral oils in inactivated avian influenza vaccine formulation.
Br Poult Sci
; 65(1): 28-33, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38038674
ABSTRACT
1. The effectiveness of inactivated vaccines depends on selecting the suitable adjuvant for vaccine formulation. The potency of vaccines with low antigen content can be improved with the appropriate adjuvant. This could allow production of more doses and lower the production cost.2. This study evaluated the efficiency of vaccines prepared using oil extracted from natural sources including argan oil, almond oil, sesame seed oil, pumpkin oil, cactus oil and black seed oil as alternative adjuvants for improving the protection capacity of inactivated influenza virus vaccine as compared to commonly used mineral oils.3. Each vaccine formulation was evaluated for stability, safety and immunogenicity in chickens, as well as for reducing the viral shedding after challenge infection.4. The cactus, sesame and pumpkin seed oil-based vaccines were found to be potent and successfully induced the production of humoral immunity in vaccinated chickens.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Influenza Aviária
Limite:
Animals
Idioma:
En
Revista:
Br Poult Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Egito