The Rocky Road to a Digital Lab.
Chimia (Aarau)
; 77(5): 300-306, 2023 May 31.
Article
em En
| MEDLINE
| ID: mdl-38047825
ABSTRACT
The pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs). The development of smart manufacturing routes can be accelerated by utilizing digitalization, process analytical technology (PAT), and data-rich experimentation from an early stage. Here, we present the key aspects of implementing automated flow chemistry reactor platforms with real-time process analytics. Based on our experiences in this field, we aim to highlight the potential of these platforms to conduct self-optimization, automated reaction model building, dynamic experiments and to implement advanced process control strategies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chimia (Aarau)
Ano de publicação:
2023
Tipo de documento:
Article