Pharmacokinetics and safety of brivaracetam in neonates with repeated electroencephalographic seizures: A multicenter, open-label, single-arm study.

Pressler, Ronit; Boylan, Geraldine; Dempsey, Eugene; Klotz, Kerstin Alexandra; Krauwinkel, Walter; Will, Edgar; Morita, Diego; Floricel, Florin; Elshoff, Jan-Peer; van den Anker, John

Pharmacokinetics and safety of brivaracetam in neonates with repeated electroencephalographic seizures: A multicenter, open-label, single-arm study.

Pressler, Ronit; Boylan, Geraldine; Dempsey, Eugene; Klotz, Kerstin Alexandra; Krauwinkel, Walter; Will, Edgar; Morita, Diego; Floricel, Florin; Elshoff, Jan-Peer; van den Anker, John.

Afiliação

Pressler R; Department of Clinical Neurophysiology, Great Ormond Street Hospital and Clinical Neuroscience, UCL-GOS Institute of Child Health, London, UK.
Boylan G; INFANT Research Centre and Department of Paediatrics and Child Health, Cork, Ireland.
Dempsey E; INFANT Research Centre and Department of Paediatrics and Child Health, Cork, Ireland.
Klotz KA; Department of Neuropediatrics and Muscle Disorders, Medical Center, University of Freiburg, Freiburg, Germany.
Krauwinkel W; UCB Pharma, Braine-l'Alleud, Belgium.
Will E; UCB Pharma, Monheim am Rhein, Germany.
Morita D; UCB Pharma, Morrisville, North Carolina, USA.
Floricel F; UCB Pharma, Monheim am Rhein, Germany.
Elshoff JP; UCB Pharma, Monheim am Rhein, Germany.
van den Anker J; Children's National Hospital, Washington, District of Columbia, USA.

Epilepsia Open ; 9(2): 522-533, 2024 Apr.

Article em En | MEDLINE | ID: mdl-38049197

Assuntos

Anticonvulsivantes; Pirrolidinonas; Convulsões; Recém-Nascido; Adulto; Criança; Humanos; Lactente; Anticonvulsivantes/efeitos adversos; Teorema de Bayes; Resultado do Tratamento; Quimioterapia Combinada; Método Duplo-Cego; Convulsões/tratamento farmacológico; Eletroencefalografia

Palavras-chave

PETITE study; antiseizure medication; neonatal seizures; tolerability; videoelectroencephalography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinonas / Convulsões / Anticonvulsivantes Limite: Adult / Child / Humans / Infant / Newborn Idioma: En Revista: Epilepsia Open Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido

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