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Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.
Ramos, Azucena; Koch, Catherine E; Liu-Lupo, Yunpeng; Hellinger, Riley D; Kyung, Taeyoon; Abbott, Keene L; Fröse, Julia; Goulet, Daniel; Gordon, Khloe S; Eidell, Keith P; Leclerc, Paul; Whittaker, Charles A; Larson, Rebecca C; Muscato, Audrey J; Yates, Kathleen B; Dubrot, Juan; Doench, John G; Regev, Aviv; Vander Heiden, Matthew G; Maus, Marcela V; Manguso, Robert T; Birnbaum, Michael E; Hemann, Michael T.
Afiliação
  • Ramos A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Koch CE; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Liu-Lupo Y; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Hellinger RD; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kyung T; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Abbott KL; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Fröse J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Goulet D; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gordon KS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Eidell KP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Leclerc P; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Whittaker CA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Larson RC; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Muscato AJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Yates KB; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Dubrot J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Doench JG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Regev A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Vander Heiden MG; Cellular Immunotherapy Program, Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Maus MV; Immunology Program, Harvard Medical School, Boston, MA, USA.
  • Manguso RT; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.
  • Birnbaum ME; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA.
  • Hemann MT; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.
Nat Commun ; 14(1): 8048, 2023 Dec 05.
Article em En | MEDLINE | ID: mdl-38052854
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Leucemia / Linfoma de Burkitt / Receptores de Antígenos Quiméricos Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Leucemia / Linfoma de Burkitt / Receptores de Antígenos Quiméricos Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos