Modeling aging and retinal degeneration with mitochondrial DNA mutation burden.

Sturgis, John; Singh, Rupesh; Caron, Quinn; Samuels, Ivy S; Shiju, Thomas Micheal; Mukkara, Aditi; Freedman, Paul; Bonilha, Vera L

Sturgis, John; Singh, Rupesh; Caron, Quinn; Samuels, Ivy S; Shiju, Thomas Micheal; Mukkara, Aditi; Freedman, Paul; Bonilha, Vera L.

Afiliação

Sturgis J; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Singh R; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Caron Q; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Samuels IS; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Shiju TM; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Mukkara A; Research Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH.
Freedman P; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Bonilha VL; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

bioRxiv ; 2023 Dec 01.

Article em En | MEDLINE | ID: mdl-38076962

Palavras-chave

Mitochondria; Polymerase gamma (POLG); aging; mitochondrial DNA (mtDNA); retina; retinal degeneration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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