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Impact of B 0 $$ {\mathrm{B}}_0 $$ field imperfections correction on BOLD sensitivity in 3D-SPARKLING fMRI data.
Amor, Zaineb; Le Ster, Caroline; Gr, Chaithya; Daval-Frérot, Guillaume; Boulant, Nicolas; Mauconduit, Franck; Thirion, Bertrand; Ciuciu, Philippe; Vignaud, Alexandre.
Afiliação
  • Amor Z; CEA, NeuroSpin, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Le Ster C; CEA, NeuroSpin, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Gr C; CEA, NeuroSpin, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Daval-Frérot G; Inria, MIND, Palaiseau, France.
  • Boulant N; CEA, NeuroSpin, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Mauconduit F; Inria, MIND, Palaiseau, France.
  • Thirion B; Siemens Healthineers, Courbevoie, France.
  • Ciuciu P; CEA, NeuroSpin, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Vignaud A; CEA, NeuroSpin, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Magn Reson Med ; 91(4): 1434-1448, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38156952
ABSTRACT

PURPOSE:

Static and dynamic B 0 $$ {\mathrm{B}}_0 $$ field imperfections are detrimental to functional MRI (fMRI) applications, especially at ultra-high magnetic fields (UHF). In this work, a field camera is used to assess the benefits of retrospectively correcting B 0 $$ {\mathrm{B}}_0 $$ field perturbations on Blood Oxygen Level Dependent (BOLD) sensitivity in non-Cartesian three-dimensional (3D)-SPARKLING fMRI acquisitions.

METHODS:

fMRI data were acquired at 1 mm 3 $$ {}^3 $$ and for a 2.4s-TR while concurrently monitoring in real-time field perturbations using a Skope Clip-on field camera in a novel experimental setting involving a shorter TR than the required minimal TR of the field probes. Measurements of the dynamic field deviations were used along with a static Δ B 0 $$ \Delta {\mathrm{B}}_0 $$ map to retrospectively correct static and dynamic field imperfections, respectively. In order to evaluate the impact of such a correction on fMRI volumes, a comparative study was conducted on healthy volunteers.

RESULTS:

Correction of B 0 $$ {\mathrm{B}}_0 $$ deviations improved image quality and yielded between 20% and 30% increase in median temporal signal-to-noise ratio (tSNR).Using fMRI data collected during a retinotopic mapping experiment, we demonstrated a significant increase in sensitivity to the BOLD contrast and improved accuracy of the BOLD phase maps 44% (resp., 159%) more activated voxels were retrieved when using a significance control level based on a p-value of 0.001 without correcting for multiple comparisons (resp., 0.05 with a false discovery rate correction).

CONCLUSION:

3D-SPARKLING fMRI hugely benefits from static and dynamic B 0 $$ {\mathrm{B}}_0 $$ imperfections correction. However, the proposed experimental protocol is flexible enough to be deployed on a large spectrum of encoding schemes, including arbitrary non-Cartesian readouts.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Imageamento por Ressonância Magnética Limite: Humans Idioma: En Revista: Magn Reson Med Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Imageamento por Ressonância Magnética Limite: Humans Idioma: En Revista: Magn Reson Med Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França