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Effects of photoperiod and food on glucose intolerance and subsequent ocular pathology in the fat sand rat.
Bilu, Carmel; Butensky, Neta; Malamud, Amit Richter; Einat, Haim; Zimmet, Paul; Zloto, Ofira; Ziv, Hana; Kronfeld-Schor, Noga; Vishnevskia-Dai, Vicktoria.
Afiliação
  • Bilu C; School of Zoology, Tel-Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel. Carmel.bilu@gmail.com.
  • Butensky N; School of Zoology, Tel-Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel.
  • Malamud AR; School of Zoology, Tel-Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel.
  • Einat H; School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv, Israel.
  • Zimmet P; Department of Medicine, Monash University, Melbourne, VIC, Australia.
  • Zloto O; Ocular Oncology, The Goldschleger Eye Institute, The Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
  • Ziv H; Maurice and Gabriela Goldschleger Eye Research Institute, The Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
  • Kronfeld-Schor N; School of Zoology, Tel-Aviv University, 69978, Ramat Aviv, Tel Aviv, Israel.
  • Vishnevskia-Dai V; Ocular Oncology, The Goldschleger Eye Institute, The Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Sci Rep ; 14(1): 403, 2024 01 03.
Article em En | MEDLINE | ID: mdl-38172147
ABSTRACT
Type 2 diabetes mellitus (T2DM) and its ocular complications, such as cataract and diabetic retinopathy (DR) have been linked to circadian rhythm-disturbances. Using a unique diurnal animal model, the sand rat (Psammomys obesus) we examined the effect of circadian disruption by short photoperiod acclimation on the development of T2DM and related ocular pathologies. We experimented with 48 male sand rats. Variables were day length (short photoperiod, SP, vs. neutral photoperiod NP) and diet (standard rodent diet vs. low-energy diet). Blood glucose, the presence of cataract and retinal pathology were monitored. Histological slides were examined for lens opacity, retinal cell count and thickness. Animals under SP and fed standard rodent diet (SPSR) for 20 weeks had higher baseline blood glucose levels and lower glucose tolerance compared with animals kept under NP regardless of diet, and under SP with low energy diet (SPLE). Animals under SPSR had less cells in the outer nuclear layer, a lower total number of cells in the retina, and a thickened retina. Higher blood glucose levels correlated with lower number of cells in all cellular layers of the retina and thicker retina. Animals under SPSR had higher occurrence of cataract, and a higher degree of cataract, which correlated with higher blood glucose levels. Sand rats kept under SPSR develop cataract and retinal abnormalities indicative of DR, whereas sand rats kept under NP regardless of diet, or under SPLE, do not. These ocular abnormalities significantly correlate with hyperglycemia.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catarata / Intolerância à Glucose / Diabetes Mellitus Tipo 2 / Retinopatia Diabética / Hiperglicemia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Israel

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catarata / Intolerância à Glucose / Diabetes Mellitus Tipo 2 / Retinopatia Diabética / Hiperglicemia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Israel