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Ketone bodies promote epididymal white adipose expansion to alleviate liver steatosis in response to a ketogenic diet.
Zhao, Meng-Fei; Zhang, Xin-Ge; Tang, Yi-Ping; Zhu, Ying-Xi; Nie, Hong-Yu; Bu, Dan-Dan; Fang, Lei; Li, Chao-Jun.
Afiliação
  • Zhao MF; Model Animal Research Center, Medical School of Nanjing University, Nanjing University, Nanjing, China.
  • Zhang XG; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.
  • Tang YP; Model Animal Research Center, Medical School of Nanjing University, Nanjing University, Nanjing, China.
  • Zhu YX; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.
  • Nie HY; Model Animal Research Center, Medical School of Nanjing University, Nanjing University, Nanjing, China.
  • Bu DD; Model Animal Research Center, Medical School of Nanjing University, Nanjing University, Nanjing, China.
  • Fang L; Model Animal Research Center, Medical School of Nanjing University, Nanjing University, Nanjing, China. Electronic address: njfanglei@nju.edu.cn.
  • Li CJ; Model Animal Research Center, Medical School of Nanjing University, Nanjing University, Nanjing, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China. Electronic address: lichaojun@njmu.edu.cn.
J Biol Chem ; 300(2): 105617, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38176653
ABSTRACT
Liver can sense the nutrient status and send signals to other organs to regulate overall metabolic homoeostasis. Herein, we demonstrate that ketone bodies act as signals released from the liver that specifically determine the distribution of excess lipid in epididymal white adipose tissue (eWAT) when exposed to a ketogenic diet (KD). An acute KD can immediately result in excess lipid deposition in the liver. Subsequently, the liver sends the ketone body ß-hydroxybutyrate (BHB) to regulate white adipose expansion, including adipogenesis and lipogenesis, to alleviate hepatic lipid accumulation. When ketone bodies are depleted by deleting 3-hydroxy-3-methylglutaryl-CoA synthase 2 gene in the liver, the enhanced lipid deposition in eWAT but not in inguinal white adipose tissue is preferentially blocked, while lipid accumulation in liver is not alleviated. Mechanistically, ketone body BHB can significantly decrease lysine acetylation of peroxisome proliferator-activated receptor gamma in eWAT, causing enhanced activity of peroxisome proliferator-activated receptor gamma, the key adipogenic transcription factor. These observations suggest that the liver senses metabolic stress first and sends a corresponding signal, that is, ketone body BHB, to specifically promote eWAT expansion to adapt to metabolic challenges.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Branco / Dieta Cetogênica / Fígado Gorduroso / Corpos Cetônicos Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Branco / Dieta Cetogênica / Fígado Gorduroso / Corpos Cetônicos Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China