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Electrochemical and Spectroscopic Studies Performed for Indomethacin and 1-Naphthol Incorporated in 1-Butyl-3-methyl-imidazolium Bis(2-ethylhexyl) Sulfosuccinate Vesicles to Investigate Them as a Potentially pH-Sensitive Nanocarrier.
Berrio Velasco, Luis F; Moyano, Fernando; Molina, Patricia G; Correa, N Mariano.
Afiliação
  • Berrio Velasco LF; Instituto para el desarrollo agroindustrial y de la salud (IDAS, CONICET-UNRC), Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal #3. C.P. , Río Cuarto X5804BYA, Argentina.
  • Moyano F; Instituto para el desarrollo agroindustrial y de la salud (IDAS, CONICET-UNRC), Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal #3. C.P. , Río Cuarto X5804BYA, Argentina.
  • Molina PG; Instituto para el desarrollo agroindustrial y de la salud (IDAS, CONICET-UNRC), Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal #3. C.P. , Río Cuarto X5804BYA, Argentina.
  • Correa NM; Instituto para el desarrollo agroindustrial y de la salud (IDAS, CONICET-UNRC), Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal #3. C.P. , Río Cuarto X5804BYA, Argentina.
Langmuir ; 40(3): 1869-1877, 2024 01 23.
Article em En | MEDLINE | ID: mdl-38194363
ABSTRACT
Characterization studies of 1-butyl-3-methyl-imidazolium bis(2-ethylhexyl) sulfosuccinate vesicles at different pH values have been carried out by using liquid surface tension, transmission electron microscopy, and dynamic light scattering. The results show that there are no vesicle changes in its size and negative Z potential at pH 3, 6, and 10. Furthermore, indomethacin and 1-naphthol, both pH-dependent, electroactive, and fluorescence probes, were used to further characterize the bilayer employing electrochemical and emission techniques. The partition of indomethacin and 1-naphthol between the water and bilayer pseudophases only occurs for the neutral species and does not happen for the anionic species because the highly negative Z bilayer potential prevents incorporation due to negative repulsion. For the neutral species, the partition constant values were evaluated by square wave voltammetry and emission spectroscopy. Finally, for the indomethacin incorporated into the vesicle bilayer at pH 3, the release profile was monitored over time at pH 6. It was found that a change in the pH values causes the complete release of indomethacin after 25 min, which led us to think that the vesicles presented in this work can be used as a pH-sensitive nanocarrier for neutral pH-sensitive drugs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinatos / Indometacina / Naftóis Tipo de estudo: Diagnostic_studies Idioma: En Revista: Langmuir Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinatos / Indometacina / Naftóis Tipo de estudo: Diagnostic_studies Idioma: En Revista: Langmuir Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina