Data mining of reference intervals for serum creatinine: an improvement in glomerular filtration rate estimating equations based on Q-values.
Clin Chem Lab Med
; 62(6): 1138-1148, 2024 May 27.
Article
em En
| MEDLINE
| ID: mdl-38205974
ABSTRACT
OBJECTIVES:
Glomerular filtration rate (GFR) estimating equations based on rescaled serum creatinine (SCr/Q) have shown better performance, where Q represents the median SCr for age- and sex-specific healthy populations. However, there remains a scarcity of investigations in China to determine this value. We aimed to develop Chinese age- and sex-specific reference intervals (RIs) and Q-values for SCr and to validate the equations incorporating new Q-values.METHODS:
We included 117,345 adults from five centers for establishing RIs and Q-values, and 3,692 participants with reference GFR (rGFR, 99mTc-DTPA renal dynamic imaging measurement) for validation. Appropriate age partitioning was determined using the decision tree method. Lower and upper reference limits and medians were calculated using the refineR algorithm, and Q-values were determined accordingly. We evaluated the full age spectrum (FAS) and European Kidney Function Consortium (EKFC) equations incorporating different Q-values considering bias, precision (interquartile range, IQR), and accuracy (percentage of estimates within ±20â¯% [P20] and ±30â¯% [P30] of rGFR).RESULTS:
RIs for males were 18-79 years, 55.53-92.50⯵mol/L; ≥80 years, 54.41-96.43⯵mol/L. RIs for females were 18-59 years, 40.42-69.73⯵mol/L; 60-79 years, 41.16-73.69⯵mol/L; ≥80 years, 46.50-73.20⯵mol/L. Q-values were set at 73.82⯵mol/L (0.84â¯mg/dL) for males and 53.80⯵mol/L (0.61â¯mg/dL) for females. After validation, we found that the adjusted equations exhibit less bias, improved precision and accuracy, and increased agreement of GFR categories.CONCLUSIONS:
We determined Chinese age- and sex-specific RIs and Q-values for SCr. The adjustable Q-values provide an effective alternative to obtain valid equations for estimating GFR.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Creatinina
/
Mineração de Dados
/
Taxa de Filtração Glomerular
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Clin Chem Lab Med
/
Clin. chem. lab. med
/
Clinical chemistry and laboratory medicine
Assunto da revista:
QUIMICA CLINICA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2024
Tipo de documento:
Article