Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size.
AIDS
; 38(8): 1120-1130, 2024 07 01.
Article
em En
| MEDLINE
| ID: mdl-38224350
ABSTRACT
OBJECTIVE:
The immunogenic nature of coronavirus disease 2019 (COVID-19) mRNA vaccines led to some initial concern that these could stimulate the HIV reservoir. We analyzed changes in plasma HIV loads (pVL) and reservoir size following COVID-19 mRNA vaccination in 62 people with HIV (PWH) receiving antiretroviral therapy (ART), and analyzed province-wide trends in pVL before and after the mass vaccination campaign.DESIGN:
Longitudinal observational cohort and province-wide analysis.METHODS:
Sixty-two participants were sampled prevaccination, and one month after their first and second COVID-19 immunizations. Vaccine-induced anti-SARS-CoV-2-Spike antibodies in serum were measured using the Roche Elecsys Anti-S assay. HIV reservoirs were quantified using the intact proviral DNA assay; pVL were measured using the cobas 6800 (lower limit of quantification 20âcopies/ml). The province-wide analysis included all 290 401 pVL performed in British Columbia, Canada between 2012 and 2022.RESULTS:
Prevaccination, the median intact reservoir size was 77 [interquartile range (IQR) 20-204] HIV copies/million CD4 + T-cells, compared to 74 (IQR 27-212) and 65 (IQR 22-174) postfirst and -second dose, respectively (all comparisons P > 0.07). Prevaccination, 82% of participants had pVL <20âcopies/ml (max 110âcopies/ml), compared to 79% postfirst dose (max 183âcopies/ml) and 85% postsecond dose (max 79âcopies/ml) ( P â>â0.4). There was no evidence that the magnitude of the vaccine-elicited anti-SARS-CoV-2-Spike immune response influenced pVL nor changes in reservoir size ( P â>â0.6). We found no evidence linking the COVID-19 mass vaccination campaign to population-level increases in detectable pVL frequency among all PWH in the province, nor among those who maintained pVL suppression on ART.CONCLUSION:
We found no evidence that COVID-19 mRNA vaccines induced changes in HIV reservoir size nor plasma viremia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viremia
/
Infecções por HIV
/
Carga Viral
/
Vacinas contra COVID-19
/
SARS-CoV-2
/
COVID-19
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá