Your browser doesn't support javascript.
loading
Vagus nerve stimulation: Potential for treating chronic wounds.
Budhiraja, Anuj; Mehta, Alisha; Alhamo, Moyasar A; Swedarsky, Richard; Dahle, Sara; Isseroff, R Rivkah.
Afiliação
  • Budhiraja A; California Northstate University College of Medicine, Elk Grove, California, USA.
  • Mehta A; California Northstate University College of Medicine, Elk Grove, California, USA.
  • Alhamo MA; Department of Dermatology, University of California, Davis, California, USA.
  • Swedarsky R; Virginia Mason Franciscan Health, Tacoma, Washington, USA.
  • Dahle S; Department of Dermatology, University of California, Davis, California, USA.
  • Isseroff RR; Podiatry Section, VA Northern California Health Care System, California, USA.
Wound Repair Regen ; 32(2): 108-117, 2024.
Article em En | MEDLINE | ID: mdl-38235529
ABSTRACT
Vagus nerve stimulation (VNS) has been approved as a treatment for various conditions, including drug-resistant epilepsy, migraines, chronic cluster headaches and treatment-resistant depression. It is known to have anti-inflammatory, anti-nociceptive and anti-adrenergic effects, and its therapeutic potential for diverse pathologies is being investigated. VNS can be achieved through invasive (iVNS) or non-invasive (niVNS) means, targeting different branches of the vagus nerve. iVNS devices require surgical implantation and have associated risks, while niVNS devices are generally better tolerated and have a better safety profile. Studies have shown that both iVNS and niVNS can reduce inflammation and pain perception in patients with acute and chronic conditions. VNS devices, such as the VNS Therapy System and MicroTransponder Vivistim, have received Food and Drug Administration approval for specific indications. Other niVNS devices, like NEMOS and gammaCore, have shown effectiveness in managing epilepsy, pain and migraines. VNS has also demonstrated potential in autoimmune disorders, such as rheumatoid arthritis and Crohn's disease, as well as neurological disorders like epilepsy and migraines. In addition, VNS has been explored in cardiovascular disorders, including post-operative atrial fibrillation and myocardial ischemia-reperfusion injury, and has shown positive outcomes. The mechanisms behind VNS's effects include the cholinergic anti-inflammatory pathway, modulation of cytokines and activation of specialised pro-resolving mediators. The modulation of inflammation by VNS presents a promising avenue for investigating its potential to improve the healing of chronic wounds. However, more research is needed to understand the specific mechanisms and optimise the use of VNS in wound healing. Ongoing clinical trials may support the use of this modality as an adjunct to improve healing.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia / Estimulação do Nervo Vago / Transtornos de Enxaqueca Limite: Humans Idioma: En Revista: Wound Repair Regen Assunto da revista: DERMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia / Estimulação do Nervo Vago / Transtornos de Enxaqueca Limite: Humans Idioma: En Revista: Wound Repair Regen Assunto da revista: DERMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos