A solid-state NMR method for characterization of pharmaceutical eutectics.

Hareendran, Chaithanya; Shaligram, Parth S; Gonnade, Rajesh; Ajithkumar, T G

Hareendran, Chaithanya; Shaligram, Parth S; Gonnade, Rajesh; Ajithkumar, T G.

Afiliação

Hareendran C; Central NMR facility and Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India. tg.ajithkumar@ncl.res.in.
Shaligram PS; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Gonnade R; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Ajithkumar TG; Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India.

Phys Chem Chem Phys ; 26(5): 3800-3803, 2024 Jan 31.

Article em En | MEDLINE | ID: mdl-38240042

ABSTRACT

ABSTRACT

Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.

Assuntos

Imageamento por Ressonância Magnética; Espectroscopia de Ressonância Magnética/métodos; Composição de Medicamentos; Preparações Farmacêuticas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética Idioma: En Revista: Phys Chem Chem Phys Assunto da revista: BIOFISICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

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