Thioglucose-derived tetrasulfide, a unique polysulfide model compound.
Redox Biol
; 70: 103045, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38245971
ABSTRACT
Polysulfides have received increased interest in redox biology due to their role as the precursors of H2S and persulfides. However, the compounds that are suitable for biological investigations are limited to cysteine- and glutathione-derived polysulfides. In this work, we report the preparation and evaluation of a novel polysulfide derived from thioglucose, which represents the first carbohydrate-based polysulfide. This compound, thioglucose tetrasulfide (TGS4), showed excellent stability and water solubility. H2S and persulfide production from TGS4, as well as its associated antioxidative property were also demonstrated. Additionally, TGS4 was demonstrated to significantly induce cellular sulfane sulfur level increase, in particular for the formation of hydropersulfides/trisulfides. These results suggest that TGS4 is a useful tool for polysulfide research.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfeto de Hidrogênio
Idioma:
En
Revista:
Redox Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos