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Effect of COVID-19 on infections associated with medical devices in critical care.
Hernández, Fredy Leonardo Carreño; Virguez, Juanita Valencia; Vesga, Juan Felipe González; Castellanos, María Lucía; Beltrán, Gabriela Ruiz; Toquica, Laura Daniela Lorza; Gomez, Carol Natalia Sánchez; Ríos, Maria Valentina Stozitzky; Bolívar, Yenny Rocío Cárdenas; Sanchez, Jorge Iván Alvarado.
Afiliação
  • Hernández FLC; School of Medicine, Universidad de los Andes, Bogotá, D.C., Colombia. fredyleonardoc@gmail.com.
  • Virguez JV; Universidad de los Andes, Bogotá, Colombia.
  • Vesga JFG; Universidad de los Andes, Bogotá, Colombia.
  • Castellanos ML; Universidad de los Andes, Bogotá, Colombia.
  • Beltrán GR; Universidad de los Andes, Bogotá, Colombia.
  • Toquica LDL; Universidad de los Andes, Bogotá, Colombia.
  • Gomez CNS; Universidad de los Andes, Bogotá, Colombia.
  • Ríos MVS; Fundación Santa Fe de Bogotá, Bogotá, Colombia.
  • Bolívar YRC; Fundación Santa Fe de Bogotá, Bogotá, Colombia.
  • Sanchez JIA; Fundación Santa Fe de Bogotá, Bogotá, Colombia.
BMC Infect Dis ; 24(1): 110, 2024 Jan 22.
Article em En | MEDLINE | ID: mdl-38254034
ABSTRACT

OBJECTIVES:

This study explores the hypothesis that COVID-19 patients are at a heightened risk of healthcare-associated infections (HAIs) associated with medical device usage compared to non-COVID-19 patients. Our primary objective was to investigate the correlation between COVID-19 infection in ICU patients and subsequent HAIs following invasive medical device insertion. Additionally, we aim to assess the impact of SARS-CoV-2 infection on onset times concerning specific microorganisms and the type of medical device, providing valuable insights into this intricate relationship in intensive care settings.

METHODOLOGY:

A retrospective cohort study was conducted using ICU patient records at our hospital from 2020 to 2022. This investigation entailed evaluating the timing of HAIs while distinguishing between patients with and without SARS-CoV-2 infection. We identified and analyzed the type of isolation and infection attributed to the medical device while controlling for ICU duration and ventilator days using Cox regression.

RESULTS:

Our study included 127 patients without SARS-CoV-2 infection and 140 patients with SARS-CoV-2 infection. The findings indicated a higher incidence of HAI caused by various microorganisms associated with any medical device in patients with SARS-CoV-2 (HR = 6.86; 95% CI-95% 3.26-14.43; p < 0.01). After adjusting for ICU duration and ventilator days, a heightened frequency of HAIs persisted in SARS-CoV-2-infected individuals. However, a detailed examination of HAIs revealed that only ventilation-associated pneumonia (VAP) displayed a significant association (HR = 6.69; 95% CI 2.59-17.31; p < 0.01). A statistically significant correlation between SARS-CoV-2 infection and the isolation of S. aureus was also observed (p = 0.034). The prevalence of S. aureus infection was notably higher in patients with SARS-CoV-2 (RR = 8.080; 95% CI 1.052-62.068; p < 0.01).

CONCLUSIONS:

The frequency of pathogen isolates in invasive medical devices exhibited an association with SARS-CoV-2 infection. Critically ill patients with SARS-CoV-2 are more prone to developing early-onset VAP than those without SARS-CoV-2 infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecção Hospitalar / COVID-19 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecção Hospitalar / COVID-19 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia