Functional Abnormality of the Reward System in Depressed Adolescents and Young Adults with and without Suicidal Behavior.
Brain Topogr
; 37(5): 889-896, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38319504
ABSTRACT
OBJECTIVE:
To identify local and functional connectivity abnormalities in the brain's reward network in depressed adolescents and young adults with and without suicidal behavior.METHODS:
Magnetic resonance imaging data were obtained from 41 major depressive disorder (MDD) patients with suicidal behavior (sMDD, males/females 12/29), 44 MDD patients without suicidal behavior (nMDD, males/females 13/32), and 52 healthy controls (HCs, males/females 17/35). The Young Mania Scale, Hamilton Depression Scale, Columbia Suicide Scale, and Scale for Suicide Ideation were used to evaluate emotional state and suicidal ideation and behaviors. The amplitude of low frequency fluctuations (ALFF), regional homogeneity (ReHo) and functional connectivity of 11 regions of interest (ROIs) in the reward network were determined.RESULTS:
ALFF values in the vmPFC of the nMDD group were significantly lower than those in the HC group (p = 0.031). The ReHo values of the nMDD group were lower in the lVS but higher in the vmPFC than those of the HC group (P = 0.018 and 0.025, respectively). Functional connectivity of the AC with the vmPFC, lVS, rVS, and vmPFC was increased in the sMDD group compared with that in the nMDD group (P = 0.038, 0.034, 0.006, respectively).CONCLUSION:
Local and functional connectivity abnormalities in the reward network were found in the MDD groups. However, increased functional connectivity was found in only the sMDD group.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recompensa
/
Imageamento por Ressonância Magnética
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Transtorno Depressivo Maior
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Brain Topogr
Assunto da revista:
CEREBRO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China