Your browser doesn't support javascript.
loading
To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.
Sciacchitano, Salvatore; Carola, Valeria; Nicolais, Giampaolo; Sciacchitano, Simona; Napoli, Christian; Mancini, Rita; Rocco, Monica; Coluzzi, Flaminia.
Afiliação
  • Sciacchitano S; Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy.
  • Carola V; Unit of Anaesthesia, Intensive Care and Pain Medicine, Sant'Andrea University Hospital, 00189 Rome, Italy.
  • Nicolais G; Department of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy.
  • Sciacchitano S; Department of Dynamic and Clinical Psychology and Health Studies, Sapienza University of Rome, 00189 Rome, Italy.
  • Napoli C; Department of Dynamic and Clinical Psychology and Health Studies, Sapienza University of Rome, 00189 Rome, Italy.
  • Mancini R; Department of Psychiatry, La Princesa University Hospital, 28006 Madrid, Spain.
  • Rocco M; Department of Surgical and Medical Science and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.
  • Coluzzi F; Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy.
J Clin Med ; 13(3)2024 Jan 26.
Article em En | MEDLINE | ID: mdl-38337415
ABSTRACT
Many factors have contributed to rendering frailty an emerging, relevant, and very popular concept. First, many pandemics that have affected humanity in history, including COVID-19, most recently, have had more severe effects on frail people compared to non-frail ones. Second, the increase in human life expectancy observed in many developed countries, including Italy has led to a rise in the percentage of the older population that is more likely to be frail, which is why frailty is much a more common concern among geriatricians compared to other the various health-care professionals. Third, the stratification of people according to the occurrence and the degree of frailty allows healthcare decision makers to adequately plan for the allocation of available human professional and economic resources. Since frailty is considered to be fully preventable, there are relevant consequences in terms of potential benefits both in terms of the clinical outcome and healthcare costs. Frailty is becoming a popular, pervasive, and almost omnipresent concept in many different contexts, including clinical medicine, physical health, lifestyle behavior, mental health, health policy, and socio-economic planning sciences. The emergence of the new "science of frailty" has been recently acknowledged. However, there is still debate on the exact definition of frailty, the pathogenic mechanisms involved, the most appropriate method to assess frailty, and consequently, who should be considered frail. This narrative review aims to analyze frailty from many different aspects and points of view, with a special focus on the proposed pathogenic mechanisms, the various factors that have been considered in the assessment of frailty, and the emerging role of biomarkers in the early recognition of frailty, particularly on the role of mitochondria. According to the extensive literature on this topic, it is clear that frailty is a very complex syndrome, involving many different domains and affecting multiple physiological systems. Therefore, its management should be directed towards a comprehensive and multifaceted holistic approach and a personalized intervention strategy to slow down its progression or even to completely reverse the course of this condition.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Clin Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Clin Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália