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Association of insulin resistance with the accumulation of saturated intramyocellular lipid: A comparison with other fat stores.
Azhar, Mueed; Watson, Laura P E; De Lucia Rolfe, Emanuella; Ferraro, Michele; Carr, Katherine; Worsley, Jieniean; Boesch, Chris; Hodson, Leanne; Chatterjee, Krishna K; Kemp, Graham J; Savage, David B; Sleigh, Alison.
Afiliação
  • Azhar M; Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Watson LPE; National Institute for Health and Care Research Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • De Lucia Rolfe E; Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Ferraro M; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Carr K; Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Worsley J; National Institute for Health and Care Research Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Boesch C; National Institute for Health and Care Research Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Hodson L; Departments of Clinical Research and Radiology AMSM, University Bern, Bern, Switzerland.
  • Chatterjee KK; Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK.
  • Kemp GJ; National Institute for Health and Care Research Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Savage DB; Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Sleigh A; Department of Musculoskeletal & Ageing Science, University of Liverpool, Liverpool, UK.
NMR Biomed ; 37(8): e5117, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38356104
ABSTRACT
It has been shown using proton magnetic resonance spectroscopy (1H MRS) that, in a group of females, whole-body insulin resistance was more closely related to accumulation of saturated intramyocellular lipid (IMCL) than to IMCL concentration alone. This has not been investigated in males. We investigated whether age- and body mass index-matched healthy males differ from the previously reported females in IMCL composition (measured as CH2CH3) and IMCL concentration (measured as CH3), and in their associations with insulin resistance. We ask whether saturated IMCL accumulation is more strongly associated with insulin resistance than other ectopic and adipose tissue lipid pools and remains a significant predictor when these other pools are taken into account. In this group of males, who had similar overall insulin sensitivity to the females, IMCL was similar between sexes. The males demonstrated similar and even stronger associations of IMCL with insulin resistance, supporting the idea that a marker reflecting the accumulation of saturated IMCL is more strongly associated with whole-body insulin resistance than IMCL concentration alone. However, this marker ceased to be a significant predictor of whole-body insulin resistance after consideration of other lipid pools, which implies that this measure carries no more information in practice than the other predictors we found, such as intrahepatic lipid and visceral adipose tissue. As the marker of saturated IMCL accumulation appears to be related to these two predictors and has a much smaller dynamic range, this finding does not rule out a role for it in the pathogenesis of insulin resistance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Metabolismo dos Lipídeos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: NMR Biomed Assunto da revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Metabolismo dos Lipídeos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: NMR Biomed Assunto da revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido