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Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields.
Gorobets, Oksana; Gorobets, Svitlana; Polyakova, Tatyana; Zablotskii, Vitalii.
Afiliação
  • Gorobets O; National Technical University of Ukraine, "Igor Sikorsky Kyiv Polytechnic Institute" Ukraine gorobets.oksana@gmail.com.
  • Gorobets S; National Technical University of Ukraine, "Igor Sikorsky Kyiv Polytechnic Institute" Ukraine gorobets.oksana@gmail.com.
  • Polyakova T; Institute of Physics of the Czech Academy of Sciences Prague Czech Republic zablot@fzu.cz.
  • Zablotskii V; Institute of Physics of the Czech Academy of Sciences Prague Czech Republic zablot@fzu.cz.
Nanoscale Adv ; 6(4): 1163-1182, 2024 Feb 13.
Article em En | MEDLINE | ID: mdl-38356636
ABSTRACT
Calcium signaling plays a crucial role in various physiological processes, including muscle contraction, cell division, and neurotransmitter release. Dysregulation of calcium levels and signaling has been linked to a range of pathological conditions such as neurodegenerative disorders, cardiovascular disease, and cancer. Here, we propose a theoretical model that predicts the modulation of calcium ion channel activity and calcium signaling in the endothelium through the application of either a time-varying or static gradient magnetic field (MF). This modulation is achieved by exerting magnetic forces or torques on either biogenic or non-biogenic magnetic nanoparticles that are bound to endothelial cell membranes. Since calcium signaling in endothelial cells induces neuromodulation and influences blood flow control, treatment with a magnetic field shows promise for regulating neurovascular coupling and treating vascular dysfunctions associated with aging and neurodegenerative disorders. Furthermore, magnetic treatment can enable control over the decoding of Ca signals, ultimately impacting protein synthesis. The ability to modulate calcium wave frequencies using MFs and the MF-controlled decoding of Ca signaling present promising avenues for treating diseases characterized by calcium dysregulation.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Nanoscale Adv Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Nanoscale Adv Ano de publicação: 2024 Tipo de documento: Article