A Simple Guide to Randomized Controlled Trials.
Int J Low Extrem Wounds
; : 15347346241236385, 2024 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-38419478
ABSTRACT
Randomized controlled trials represent the cornerstone for the regulatory approval of drugs and evidence-based medicine and policy. Compared with observational studies random assignment of participants to each study arm guarantees an equal distribution of potential confounders thus achieving impartiality in the evaluation of between group differences and allowing for causal inferences to be drawn. These complex and costly medical experiments are tightly regulated and require substantial planning with great attention to several methodological aspects ranging from allocation concealment and blinding to sample size estimation, statistical analysis, and handling of protocol deviations. This brief guide offers useful insights into the design, conduct, and interpretation of clinical trial findings for beginners.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Int J Low Extrem Wounds
Assunto da revista:
TRAUMATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Grécia