Capturing the unpredictability of stem cells.

Durmaz, Arda; Visconte, Valeria

Durmaz, Arda; Visconte, Valeria.

Afiliação

Durmaz A; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States.
Visconte V; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States.

Elife ; 132024 Mar 01.

Article em En | MEDLINE | ID: mdl-38427029

ABSTRACT

ABSTRACT

A new mathematical model that can be applied to both single-cell and bulk DNA sequencing data sheds light on the processes governing population dynamics in stem cells.

Assuntos

Células-Tronco; Mutação; Análise de Sequência de DNA

Palavras-chave

evolutionary biology; evolutionary inferences; healthy human tissues; human; sampling; single cell mutation burden; stem cell dynamics; variant allele frequency

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Idioma: En Revista: Elife Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

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