Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan.
Environ Int
; 185: 108542, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38461779
ABSTRACT
BACKGROUND:
Epidemiological evidence has demonstrated an association between arsenic in drinking water and increased cancer incidence. This population-based study investigates the impact of a tap water supply system installation in Blackfoot disease-endemic regions of Taiwan on cancer incidence.METHODS:
By using the Taiwan Cancer Registry dataset, we enrolled patients aged 40-84 diagnosed with arsenic-related cancers, including hepatocellular carcinoma, small and squamous cell lung cancer, Bowen's disease, basal and squamous cell skin cancer, urothelial bladder cancer, and upper tract urothelial carcinoma between 1995 and 2019. Random-effects age-period-cohort models were used to estimate the cancer incidence data, and a stabilized kriging method was employed to interpolate incidence rates to more precise spatiotemporal units.RESULTS:
The results showed that the age-standardized incidence rates of all six types of studied cancers were consistently higher in Blackfoot disease-endemic areas than those in other areas from 1995 to 2019. However, the gap in incidence rates between Blackfoot disease-endemic areas and the remaining regions began to narrow approximately after the 1960 birth cohort when the tap water supply system installation commenced. For small and squamous cell lung cancer, Bowen's disease, and urothelial bladder cancer, the excess incidence rates sharply declined to null for those born after the year of arsenic mitigation. For upper tract urothelial carcinoma, the excess incidence rates decreased more gradually for those born after the year of arsenic mitigation. For hepatocellular carcinoma and basal and squamous cell skin cancer, the excess incidence rates remained constant. Spatiotemporal clusters of high incidence rates were identified in the core townships of Blackfoot disease-endemic areas. These clusters began to dissipate mainly after the 1960 birth cohort.CONCLUSION:
Arsenic mitigation from drinking water in Taiwan is associated with a reduced burden of small and squamous cell lung cancers, Bowen's disease, urothelial bladder cancer, and upper tract urothelial carcinoma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arsênio
/
Neoplasias Cutâneas
/
Poluentes Químicos da Água
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Água Potável
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Neoplasias da Bexiga Urinária
/
Doença de Bowen
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Carcinoma de Células de Transição
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Carcinoma Hepatocelular
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Neoplasias Hepáticas
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Neoplasias Pulmonares
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Environ Int
/
Environ. int
/
Environment international
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Taiwan