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Pathogenic Potential of Eomesodermin-Expressing T-Helper Cells in Neurodegenerative Diseases.
Kanazawa, Tomomi; Sato, Wakiro; Raveney, Ben J E; Takewaki, Daiki; Kimura, Atsuko; Yamaguchi, Hiromi; Yokoi, Yuma; Saika, Reiko; Takahashi, Yuji; Fujita, Tsuneo; Saiki, Shinji; Tamaoka, Akira; Oki, Shinji; Yamamura, Takashi.
Afiliação
  • Kanazawa T; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Sato W; Department of Neurology, Hitachi General Hospital, Hitachi, Japan.
  • Raveney BJE; Department of Neurology, Tsukuba University Graduate School of Medicine, Tsukuba, Japan.
  • Takewaki D; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Kimura A; Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Yamaguchi H; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Yokoi Y; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Saika R; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Takahashi Y; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
  • Fujita T; Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Saiki S; Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Tamaoka A; Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Oki S; Department of Neurology, Hitachi General Hospital, Hitachi, Japan.
  • Yamamura T; Department of Neurology, Tsukuba University Graduate School of Medicine, Tsukuba, Japan.
Ann Neurol ; 95(6): 1093-1098, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38516846
ABSTRACT
Eomesodermin-expressing (Eomes+) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes+ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes+ Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024;951093-1098.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Auxiliares-Indutores / Doenças Neurodegenerativas / Proteínas com Domínio T Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Auxiliares-Indutores / Doenças Neurodegenerativas / Proteínas com Domínio T Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão