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Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice.
Bian, Jiaxin; Chen, Hongyu; Sun, Junhui; Han, Shuai; Qi, Ming; Pan, Qing.
Afiliação
  • Bian J; Department of Ophthalmology, Zhejiang University Medical School First Affiliated Hospital, Hangzhou, 310000, China; Department of Cell Biology and Medical Genetics, School of Medicine Zhejiang University, Hangzhou, 310000, China; HVP-China, Hangzhou, 310000, China.
  • Chen H; Department of Cell Biology and Medical Genetics, School of Medicine Zhejiang University, Hangzhou, 310000, China.
  • Sun J; Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Han S; Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital(Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310000, China.
  • Qi M; Department of Ophthalmology, Zhejiang University Medical School First Affiliated Hospital, Hangzhou, 310000, China; Department of Cell Biology and Medical Genetics, School of Medicine Zhejiang University, Hangzhou, 310000, China; Assisted Reproduction Unit, Department of Obstetrics and Gynecology, D
  • Pan Q; Department of Ophthalmology, Zhejiang University Medical School First Affiliated Hospital, Hangzhou, 310000, China. Electronic address: panqing_2024@126.com.
Biochem Biophys Res Commun ; 709: 149809, 2024 05 21.
Article em En | MEDLINE | ID: mdl-38552555
ABSTRACT
Hyperuricemia is a chronic metabolic disease caused by purine metabolism disorder. And several gene loci and transporter proteins that associated with uric acid transport functions have been identified. Retinol Dehydrogenase 12 (RDH12), recognized for its role in safeguarding photoreceptors, and our study investigated the potential impact of Rdh12 mutations on other organs and diseases, particularly hyperuricemia. We assessed Rdh12 mRNA expression levels in various tissues and conducted serum biochemical analyses in Rdh12-/- mice. Compared with the wild type, significant alterations in serum uric acid levels and kidney-related biochemical indicators have been revealed. Then further analysis, including quantitative RT-PCR of gene expression in the liver and kidney, highlighted variations in the expression levels of specific genes linked to hyperuricemia. And renal histology assessment exposed mild pathological lesions in the kidneys of Rdh12-/- mice. In summary, our study suggests that Rdh12 mutations impact not only retinal function but also contribute to hyperuricemia and renal disease phenotypes in mice. Our finding implies that individuals with Rdh12 mutations may be prone to hyperuricemia and gout, emphasizing the significance of preventive measures and regular examinations in daily life.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperuricemia Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperuricemia Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China