DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson's disease.

Yu, Seong-Jin; Wang, Yun; Shen, Hui; Bae, Eun-Kyung; Li, Yazhou; Sambamurti, Kumar; Tones, Michael A; Zaleska, Margaret M; Hoffer, Barry J; Greig, Nigel H

Yu, Seong-Jin; Wang, Yun; Shen, Hui; Bae, Eun-Kyung; Li, Yazhou; Sambamurti, Kumar; Tones, Michael A; Zaleska, Margaret M; Hoffer, Barry J; Greig, Nigel H.

Afiliação

Yu SJ; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, 35053, Taiwan.
Wang Y; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, 35053, Taiwan. ywang@nhri.edu.tw.
Shen H; National Institute On Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA. ywang@nhri.edu.tw.
Bae EK; National Institute On Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA.
Li Y; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, 35053, Taiwan.
Sambamurti K; National Institute On Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA.
Tones MA; Department of Neurosciences, the Medical University of South Carolina, Charleston, SC, 29425, USA.
Zaleska MM; Cadre Bioscience, Saint Louis, MO, 63110, USA.
Hoffer BJ; Neuro-D Consulting LLC, Penn Valley, PA, 19072, USA.
Greig NH; Department of Neurosurgery, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.

Geroscience ; 46(5): 4349-4371, 2024 Oct.

Article em En | MEDLINE | ID: mdl-38563864

Assuntos

Inibidores da Dipeptidil Peptidase IV; Neurônios Dopaminérgicos; Oxidopamina; Fosfato de Sitagliptina; Animais; Fosfato de Sitagliptina/farmacologia; Inibidores da Dipeptidil Peptidase IV/farmacologia; Masculino; Neurônios Dopaminérgicos/efeitos dos fármacos; Neurônios Dopaminérgicos/metabolismo; Ratos; Humanos; Ratos Sprague-Dawley; Modelos Animais de Doenças; Doenças Neuroinflamatórias/tratamento farmacológico; Transtornos Parkinsonianos/tratamento farmacológico; Transtornos Parkinsonianos/metabolismo; Transtornos Parkinsonianos/induzido quimicamente; Incretinas/farmacologia

Palavras-chave

6-hydroxydopamine; Dopamine; GIP; Gliptins; Incretins, GLP-1; Neurodegeneration; Neurogenesis; Neuroinflammation; PF-00734,200; Parkinson's disease; Sitagliptin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidopamina / Inibidores da Dipeptidil Peptidase IV / Neurônios Dopaminérgicos / Fosfato de Sitagliptina Limite: Animals / Humans / Male Idioma: En Revista: Geroscience Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan

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