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Prandial Insulins: A Person-Centered Choice.
Attri, Bhawna; Nagendra, Lakshmi; Dutta, Deep; Shetty, Sahana; Shaikh, Shehla; Kalra, Sanjay; Bhattacharya, Saptarshi.
Afiliação
  • Attri B; Department of Endocrinology, Sarvodaya Hospital, Faridabad, Haryana, India.
  • Nagendra L; Department of Endocrinology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
  • Dutta D; Department of Endocrinology, Center for Endocrinology Diabetes Arthritis and Rheumatism (CEDAR) Super-Speciality Healthcare, Dwarka, Delhi, India.
  • Shetty S; Department of Endocrinology, Kasturba Medical College, Manipal, Karnataka, India.
  • Shaikh S; Department of Endocrinology, Saifee Hospital, Mumbai, Maharashtra, India.
  • Kalra S; Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
  • Bhattacharya S; Department of Endocrinology, Indraprastha Apollo Hospitals, Sarita Vihar, Mathura Road, Delhi, 110076, India. saptarshi515@gmail.com.
Curr Diab Rep ; 24(6): 131-145, 2024 06.
Article em En | MEDLINE | ID: mdl-38568467
ABSTRACT
PURPOSE OF REVIEW Postprandial hyperglycemia, or elevated blood glucose after meals, is associated with the development and progression of various diabetes-related complications. Prandial insulins are designed to replicate the natural insulin release after meals and are highly effective in managing post-meal glucose spikes. Currently, different types of prandial insulins are available such as human regular insulin, rapid-acting analogs, ultra-rapid-acting analogs, and inhaled insulins. Knowledge about diverse landscape of prandial insulin will optimize glycemic management. RECENT

FINDINGS:

Human regular insulin, identical to insulin produced by the human pancreas, has a slower onset and extended duration, potentially leading to post-meal hyperglycemia and later hypoglycemia. In contrast, rapid-acting analogs, such as lispro, aspart, and glulisine, are new insulin types with amino acid modifications that enhance their subcutaneous absorption, resulting in a faster onset and shorter action duration. Ultra-rapid analogs, like faster aspart and ultra-rapid lispro, offer even shorter onset of action, providing better meal-time flexibility. The Technosphere insulin offers an inhaled route for prandial insulin delivery. The prandial insulins can be incorporated into basal-bolus, basal plus, or prandial-only regimens or delivered through insulin pumps. Human regular insulin, aspart, lispro, and faster aspart are recommended for management of hyperglycemia during pregnancy. Ongoing research is focused on refining prandial insulin replacement and exploring newer delivery methods. The article provides a comprehensive overview of various prandial insulin options and their clinical applications in the management of diabetes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipoglicemiantes Limite: Female / Humans / Pregnancy Idioma: En Revista: Curr Diab Rep Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipoglicemiantes Limite: Female / Humans / Pregnancy Idioma: En Revista: Curr Diab Rep Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia